The Docking Protein FRS2α Is an Essential Component of Multiple Fibroblast Growth Factor Responses during Early Mouse Development

The docking protein FRS2α is a major mediator of fibroblast growth factor (FGF) signaling. However, the physiological role of FRS2α in vivo remains unknown. In this report, we show that Frs2α-null mouse embryos have a defect in anterior-posterior (A-P) axis formation and are developmentally retarded...

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Autori principali: Gotoh, N., Manova, K., Tanaka, S., Murohashi, M., Hadari, Y., Lee, A., Hamada, Y., Hiroe, T., Ito, M., Kurihara, T., Nakazato, H., Shibuya, M., Lax, I., Lacy, E., Schlessinger, J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2005
Soggetti:
Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087717/
https://ncbi.nlm.nih.gov/pubmed/15870281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4105-4116.2005
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