Silencing Mitosin Induces Misaligned Chromosomes, Premature Chromosome Decondensation before Anaphase Onset, and Mitotic Cell Death

Mitosin (also named CENP-F) is a large human nuclear protein transiently associated with the outer kinetochore plate in M phase. Using RNA interference and fluorescence microscopy, we showed that mitosin depletion attenuated chromosome congression and led to metaphase arrest with misaligned polar ch...

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Detalhes bibliográficos
Main Authors: Yang, Zhenye, Guo, Jing, Chen, Qi, Ding, Chong, Du, Juan, Zhu, Xueliang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Chromosome Structure and Dynamics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087709/
https://ncbi.nlm.nih.gov/pubmed/15870278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.10.4062-4074.2005
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