Antibiotic-Free Plasmid Stabilization by Operator-Repressor Titration for Vaccine Delivery by Using Live Salmonella enterica Serovar Typhimurium

Live, attenuated bacteria are effective vectors for heterologous antigen delivery. However, loss of heterologous gene-bearing plasmids is problematic, and antibiotics and their resistance genes are not desirable for in vivo DNA vaccine delivery due to biosafety and regulatory concerns. To solve this...

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Bibliografiske detaljer
Main Authors: Garmory, Helen S., Leckenby, Matthew W., Griffin, Kate F., Elvin, Stephen J., Taylor, Rosa R., Hartley, M. Gill, Hanak, Julian A. J., Williamson, E. Diane, Cranenburgh, Rocky M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2005
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087430/
https://ncbi.nlm.nih.gov/pubmed/15784541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.4.2005-2011.2005
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