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Local Phosphatidylinositol 3,4,5-Trisphosphate Accumulation Recruits Vav2 and Vav3 to Activate Rac1/Cdc42 and Initiate Neurite Outgrowth in Nerve Growth Factor-stimulated PC12 Cells

Neurite outgrowth is an important process in the formation of neuronal networks. Rac1 and Cdc42, members of the Rho-family GTPases, positively regulate neurite extension through reorganization of the actin cytoskeleton. Here, we examine the dynamic linkage between Rac1/Cdc42 and phosphatidylinositol...

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Detalles Bibliográficos
Main Authors: Aoki, Kazuhiro, Nakamura, Takeshi, Fujikawa, Keiko, Matsuda, Michiyuki
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1087229/
https://ncbi.nlm.nih.gov/pubmed/15728722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-10-0904
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