Disruption of an Internal Membrane-Spanning Region in Shiga Toxin 1 Reduces Cytotoxicity

Shiga toxin type 1 (Stx1) belongs to the Shiga family of bipartite AB toxins that inactivate eukaryotic 60S ribosomes. The A subunit of Stxs are N-glycosidases that share structural and functional features in their catalytic center and in an internal hydrophobic region that shows strong transmembran...

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Publié dans:	Infect Immun
Auteurs principaux:	Suhan, Michelle L., Hovde, Carolyn J.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 1998
Sujets:	Molecular and Cellular Pathogenesis
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108656/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9784530/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.11.5252-5259.1998
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