Purification, Potency, and Efficacy of the Botulinum Neurotoxin Type A Binding Domain from Pichia pastoris as a Recombinant Vaccine Candidate

Recombinant botulinum neurotoxin serotype A binding domain [BoNT/A(H(c))], expressed in Pichia pastoris, was developed as a vaccine candidate for preventing botulinum neurotoxin type A (BoNT/A) intoxication. After fermentation and cell disruption, BoNT/A(H(c)) was purified by using a three-step chro...

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Bibliografische Detailangaben

Veröffentlicht in:	Infect Immun
Hauptverfasser:	Byrne, Michael P., Smith, Theresa J., Montgomery, Vicki A., Smith, Leonard A.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108595/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9746584/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.10.4817-4822.1998
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