Differential effects of the protein cofactor on the interactions between an RNase P ribozyme and its target mRNA substrate

RNase P from Escherichia coli is a tRNA-processing enzyme and consists of a catalytic RNA subunit (M1 RNA) and a protein component (C5 protein). M1GS, a gene-targeting ribozyme derived from M1, can cleave a herpes simplex virus 1 mRNA efficiently in vitro and inhibit its expression effectively in vi...

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izdano v:	Nucleic Acids Res
Principais autores:	Hsu, Amy W., Kilani, Ahmed F., Liou, Kwa, Lee, Jarone, Liu, Fenyong
Format:	Artigo
Jezik:	Inglês
Izdano:	Oxford University Press 2000
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10931926/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/28.16.3105
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