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Human RNA Polymerase II Elongation in Slow Motion: Role of the TFIIF RAP74 α1 Helix in Nucleoside Triphosphate-Driven Translocation
The role of the RAP74 α1 helix of transcription factor IIF (TFIIF) in stimulating elongation by human RNA polymerase II (RNAP II) was examined using millisecond-phase transient-state kinetics. RAP74 deletion mutants RAP74(1-227), which includes an intact α1 helix, and RAP74(1-158), in which the α1 h...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084311/ https://ncbi.nlm.nih.gov/pubmed/15831464 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3583-3595.2005 |
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