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Id2 Mediates Tumor Initiation, Proliferation, and Angiogenesis in Rb Mutant Mice
The inhibitor of differentiation Id2 is a target of the retinoblastoma (Rb) protein during mouse embryogenesis. In Rb(+/−) mice, LOH at the wild-type Rb allele initiates pituitary adenocarcinoma, a tumor derived from embryonic melanotropes. Here we identify a critical role for Id2 in initiation, gro...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084294/ https://ncbi.nlm.nih.gov/pubmed/15831462 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.9.3563-3574.2005 |
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