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Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation
The breast cancer predisposition gene BRCA2 encodes a protein involved in the repair of DNA double-strand breaks, which arise spontaneously and following exposure to ionizing radiation (IR). To develop a mouse model that examines the effect of BRCA2 mutation and IR exposure on in vivo somatic mutati...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Oxford University Press
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084010/ https://ncbi.nlm.nih.gov/pubmed/11850397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf037 |
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