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Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

The breast cancer predisposition gene BRCA2 encodes a protein involved in the repair of DNA double-strand breaks, which arise spontaneously and following exposure to ionizing radiation (IR). To develop a mouse model that examines the effect of BRCA2 mutation and IR exposure on in vivo somatic mutati...

詳細記述

保存先:
書誌詳細
主要な著者: Tutt, Andrew N.J., van Oostrom, Conny Th.M., Ross, Gillian M., van Steeg, Harry, Ashworth, Alan
フォーマット: Artigo
言語:Inglês
出版事項: Oxford University Press 2002
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084010/
https://ncbi.nlm.nih.gov/pubmed/11850397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf037
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