Disruption of Brca2 increases the spontaneous mutation rate in vivo: synergism with ionizing radiation

The breast cancer predisposition gene BRCA2 encodes a protein involved in the repair of DNA double-strand breaks, which arise spontaneously and following exposure to ionizing radiation (IR). To develop a mouse model that examines the effect of BRCA2 mutation and IR exposure on in vivo somatic mutati...

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Bibliographic Details
Main Authors: Tutt, Andrew N.J., van Oostrom, Conny Th.M., Ross, Gillian M., van Steeg, Harry, Ashworth, Alan
Format: Artigo
Language:Inglês
Published: Oxford University Press 2002
Subjects:
Scientific Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1084010/
https://ncbi.nlm.nih.gov/pubmed/11850397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf037
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