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Boundary-independent polar nonsense-mediated decay
Nonsense-mediated decay (NMD) is an RNA surveillance mechanism that degrades mRNAs containing premature termination (nonsense) codons. The second signal for this pathway in mammalian cells is an intron that must be at least ∼55 nucleotides downstream of the nonsense codon. Although the functional si...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1084009/ https://ncbi.nlm.nih.gov/pubmed/11850396 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvf036 |
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