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Telomerase subunit overexpression suppresses telomere-specific checkpoint activation in the yeast yku80 mutant
Ku is a conserved heterodimeric DNA-binding protein that plays critical roles in DNA repair and telomere homeostasis. In Saccharomyces cerevisiae, deletion of YKU70 or YKU80 results in an inability to grow at 37°C. This is suppressed by overexpression of several components of telomerase (EST1, EST2...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1083835/ https://ncbi.nlm.nih.gov/pubmed/11266360 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kve038 |
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