Inducible Nitric Oxide Synthase-Deficient Mice Develop Enhanced Type 1 Cytokine-Associated Cellular and Humoral Immune Responses after Vaccination with Attenuated Schistosoma mansoni Cercariae but Display Partially Reduced Resistance

High levels of nitric oxide (NO) are produced by inducible nitric oxide synthase (iNOS) in response to activating signals from Th1-associated cytokines and play an important role in cytotoxicity and cytostasis against many pathogenic microorganisms. In addition to its direct effector function, NO se...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	James, Stephanie L., Cheever, Allen W., Caspar, Patricia, Wynn, Thomas A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Fungal and Parasitic Infections
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108380/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9673227/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.8.3510-3518.1998
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