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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

Ku86 together with Ku70, DNA-PKcs, XRCC4 and DNA ligase IV forms a complex involved in repairing DNA double-strand breaks (DSB) in mammals. Yeast Ku has an essential role at the telomere; in particular, Ku deficiency leads to telomere shortening, loss of telomere clustering, loss of telomeric silenc...

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Detalhes bibliográficos
Main Authors: Samper, Enrique, Goytisolo, Fermín A., Slijepcevic, Predrag, van Buul, Paul P.W., Blasco, María A.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2000
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1083725/
https://ncbi.nlm.nih.gov/pubmed/11256607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/embo-reports/kvd051
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