Intrapulmonary Delivery of Tumor Necrosis Factor Agonist Peptide Augments Host Defense in Murine Gram-Negative Bacterial Pneumonia

Tumor necrosis factor alpha (TNF) has been shown to be an essential cytokine mediator of innate immunity in Klebsiella pneumonia. Recently, a TNF agonist peptide consisting of the 11-amino-acid TNF binding site (TNF(70-80)) has been shown to possess many of the leukocyte-activating properties of TNF...

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Autors principals: Laichalk, Lauri L., Bucknell, Kathy A., Huffnagle, Gary B., Wilkowski, Jodi M., Moore, Thomas A., Romanelli, Robert J., Standiford, Theodore J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1998
Matèries:
Host Response and Inflammation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC108277/
https://ncbi.nlm.nih.gov/pubmed/9596755
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