Campylobacter jejuni Cytolethal Distending Toxin Causes a G(2)-Phase Cell Cycle Block

Cytolethal distending toxin (CDT) from the diarrheagenic bacterium Campylobacter jejuni was shown to cause a rapid and specific cell cycle arrest in HeLa and Caco-2 cells. Within 24 h of treatment, CDT caused HeLa cells to arrest with a 4N DNA content, indicative of cells in G(2) or early M phase. I...

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Pubblicato in:	Infect Immun
Autori principali:	Whitehouse, Chris A., Balbo, Paul B., Pesci, Everett C., Cottle, Daniel L., Mirabito, Peter M., Pickett, Carol L.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1998
Soggetti:	Molecular and Cellular Pathogenesis
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC108146/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9573072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.66.5.1934-1940.1998
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