Campylobacter jejuni Cytolethal Distending Toxin Causes a G(2)-Phase Cell Cycle Block

Cytolethal distending toxin (CDT) from the diarrheagenic bacterium Campylobacter jejuni was shown to cause a rapid and specific cell cycle arrest in HeLa and Caco-2 cells. Within 24 h of treatment, CDT caused HeLa cells to arrest with a 4N DNA content, indicative of cells in G(2) or early M phase. I...

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Hauptverfasser: Whitehouse, Chris A., Balbo, Paul B., Pesci, Everett C., Cottle, Daniel L., Mirabito, Peter M., Pickett, Carol L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 1998
Schlagworte:
Molecular and Cellular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC108146/
https://ncbi.nlm.nih.gov/pubmed/9573072
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