Defective Nitric Oxide Effector Functions Lead to Extreme Susceptibility of Trypanosoma cruzi-Infected Mice Deficient in Gamma Interferon Receptor or Inducible Nitric Oxide Synthase

Trypanosoma cruzi, the causative agent of Chagas’ disease, induces an innate and adaptive host immune response during the acute phase of infection. These responses were analyzed by comparing mouse lines deficient for the gamma interferon (IFN-γ) receptor (IFN-γR(−/−)) or deficient for inducible nitr...

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Main Authors: Hölscher, Christoph, Köhler, Gabriele, Müller, Uwe, Mossmann, Horst, Schaub, Günter A., Brombacher, Frank
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Fungal and Parasitic Infections
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC108035/
https://ncbi.nlm.nih.gov/pubmed/9488415
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