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Dexamethasone inhibits the HSV-tk/ ganciclovir bystander effect in malignant glioma cells

BACKGROUND: HSV-tk/ ganciclovir (GCV) gene therapy has been extensively studied in the setting of brain tumors and largely relies on the bystander effect. Large studies have however failed to demonstrate any significant benefit of this strategy in the treatment of human brain tumors. Since dexametha...

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Detalhes bibliográficos
Main Authors: Robe, Pierre A, Nguyen-Khac, Minh, Jolois, Olivier, Rogister, Bernard, Merville, Marie-Paule, Bours, Vincent
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1080125/
https://ncbi.nlm.nih.gov/pubmed/15804364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-5-32
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