Overexpression of Bcl-2 is associated with apoptotic resistance to the G-quadruplex ligand 12459 but is not sufficient to confer resistance to long-term senescence

The triazine derivative 12459 is a potent G-quadruplex interacting agent that inhibits telomerase activity. This agent induces time- and dose-dependent telomere shortening, senescence-like growth arrest and apoptosis in the human A549 tumour cell line. We show here that 12459 induces a delayed apopt...

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Bibliographische Detailangaben
Hauptverfasser: Douarre, Céline, Gomez, Dennis, Morjani, Hamid, Zahm, Jean-Marie, O'Donohue, Marie-Françoise, Eddabra, Lahcen, Mailliet, Patrick, Riou, Jean-François, Trentesaux, Chantal
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1079972/
https://ncbi.nlm.nih.gov/pubmed/15831792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki514
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