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Msx2 promotes cardiovascular calcification by activating paracrine Wnt signals
In diabetic LDLR–/– mice, an ectopic BMP2-Msx2 gene regulatory program is upregulated in association with vascular calcification. We verified the procalcific actions of aortic Msx2 expression in vivo. CMV-Msx2 transgenic (CMV-Msx2Tg(+)) mice expressed 3-fold higher levels of aortic Msx2 than nontran...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Clinical Investigation
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1077175/ https://ncbi.nlm.nih.gov/pubmed/15841209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200524140 |
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