The Escherichia coli cmlA Gene Encodes the Multidrug Efflux Pump Cmr/MdfA and Is Responsible for Isopropyl-β-d-Thiogalactopyranoside Exclusion and Spectinomycin Sensitivity

Expression of cloned genes from isopropyl-β-d-thiogalactopyranoside (IPTG)-regulated promoters is lowered when the Escherichia coli CmlA/Cmr/MdfA efflux pump is overexpressed, probably due to IPTG exclusion from the cytoplasm. The previously reported cmlA1 mutation confers a similar phenotype. cmlA1...

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Bibliographic Details
Main Authors: Bohn, Chantal, Bouloc, Philippe
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC107689/
https://ncbi.nlm.nih.gov/pubmed/9811673
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