A Noninfectious Simian/Human Immunodeficiency Virus DNA Vaccine That Protects Macaques against AIDS

Simian/human immunodeficiency virus SHIV(KU2) replicates with extremely high titers in macaques. In order to determine whether the DNA of the viral genome could be used as a vaccine if the DNA were rendered noninfectious, we deleted the reverse transcriptase gene from SHIV(KU2) and inserted this DNA...

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Bibliographic Details
Main Authors: Singh, Dinesh K., Liu, Zhenqian, Sheffer, Darlene, Mackay, Glenn A., Smith, Marilyn, Dhillon, Sukhbir, Hegde, Ramakrishna, Jia, Fenglan, Adany, Istvan, Narayan, Opendra
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2005
Subjects:
Vaccines and Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1075712/
https://ncbi.nlm.nih.gov/pubmed/15731236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.6.3419-3428.2005
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