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Site-specific incorporation of N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF) into oligonucleotides using modified ‘ultra-mild’ DNA synthesis

Aromatic amino and nitro compounds are potent carcinogens found in the environment that exert their toxic effects by reacting with DNA following metabolic activation. One important adduct is N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-AAF), which has been extensively used in studies of the mech...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Gillet, Ludovic C. J., Alzeer, Jawad, Schärer, Orlando D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2005
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1074722/
https://ncbi.nlm.nih.gov/pubmed/15814813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki335
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