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Increased glutamate synaptic transmission in the nucleus raphe magnus neurons from morphine-tolerant rats

Currently, opioid-based drugs are the most effective pain relievers that are widely used in the treatment of pain. However, the analgesic efficacy of opioids is significantly limited by the development of tolerance after repeated opioid administration. Glutamate receptors have been reported to criti...

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Bibliographic Details
Main Authors: Bie, Bihua, Pan, Zhizhong Z
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1074357/
https://ncbi.nlm.nih.gov/pubmed/15813995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-1-7
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