Substitution of an Alanine Residue for Glycine 146 in TMP Kinase from Escherichia coli Is Responsible for Bacterial Hypersensitivity to Bromodeoxyuridine

The wild-type TMP kinases from Escherichia coli and from a strain hypersensitive to 5-bromo-2′-deoxyuridine were characterized comparatively. The mutation at codon 146 causes the substitution of an alanine residue for glycine in the enzyme, which is accompanied by changes in the relative affinities...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Tourneux, Lise, Bucurenci, Nadia, Lascu, Ioan, Sakamoto, Hiroshi, Briand, Gilbert, Gilles, Anne-Marie
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Enzymes and Proteins
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC107429/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9696781/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.180.16.4291-4293.1998
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