Effect of buffer additives on solubilization and refolding of reteplase inclusion bodies

Reteplase is a non-glycosylated and recombinant form of tissue type plasminogen activator, which is produced in Escherichia coli. However, its overexpression usually leads to formation of inactive aggregates or inclusion bodies. In the present study, we report on the development of optimized process...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Iman Esmaili, Hamid Mir Mohammad Sadeghi, Vajihe Akbari
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Wolters Kluwer Medknow Publications 2018-01-01
Σειρά:	Research in Pharmaceutical Sciences
Θέματα:	chemical chaperone; inclusion bodies; refolding additives; reteplase
Διαθέσιμο Online:	http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=5;spage=413;epage=421;aulast=Esmaili
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