Effect of buffer additives on solubilization and refolding of reteplase inclusion bodies

Reteplase is a non-glycosylated and recombinant form of tissue type plasminogen activator, which is produced in Escherichia coli. However, its overexpression usually leads to formation of inactive aggregates or inclusion bodies. In the present study, we report on the development of optimized process...

Descripció completa

Dades bibliogràfiques

Autors principals:	Iman Esmaili, Hamid Mir Mohammad Sadeghi, Vajihe Akbari
Format:	Artigo
Idioma:	Inglês
Publicat:	Wolters Kluwer Medknow Publications 2018-01-01
Col·lecció:	Research in Pharmaceutical Sciences
Matèries:	chemical chaperone; inclusion bodies; refolding additives; reteplase
Accés en línia:	http://www.rpsjournal.net/article.asp?issn=1735-5362;year=2018;volume=13;issue=5;spage=413;epage=421;aulast=Esmaili
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!