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The Carboxyl Terminus of VEGFR-2 Is Required for PKC-mediated Down-Regulation

Vascular endothelial growth factor receptor-2 (VEGFR-2/Flk-1) is a receptor tyrosine kinase (RTK) whose activation regulates angiogenesis. The regulatory mechanisms that attenuate VEGFR-2 signal relay are largely unknown. Our study shows that VEGFR-2 promotes phosphorylation of c-Cbl, but activation...

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Detalles Bibliográficos
Autores principales: Singh, Amrik J., Meyer, Rosana D., Band, Hamid, Rahimi, Nader
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society for Cell Biology 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1073687/
https://ncbi.nlm.nih.gov/pubmed/15673613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-08-0749
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