Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice

Patients with germ line mutations in the VHL tumor suppressor gene are predisposed to the development of highly vascularized tumors within multiple tissues. Loss of pVHL results in constitutive activation of the transcription factors HIF-1 and HIF-2, whose relative contributions to the pathogenesis...

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Bibliographische Detailangaben
Hauptverfasser: Rankin, Erinn B., Higgins, Debra F., Walisser, Jacqueline A., Johnson, Randall S., Bradfield, Christopher A., Haase, Volker H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Gene Expression
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069599/
https://ncbi.nlm.nih.gov/pubmed/15798202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.8.3163-3172.2005
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