The role of insulin receptor substrate 2 in hypothalamic and β cell function

Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in β cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons (POMCCreIrs2KO) to determine the role of Irs2 in the CNS...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Choudhury, Agharul I., Heffron, Helen, Smith, Mark A., Al-Qassab, Hind, Xu, Allison W., Selman, Colin, Simmgen, Marcus, Clements, Melanie, Claret, Marc, MacColl, Gavin, Bedford, David C., Hisadome, Kazunari, Diakonov, Ivan, Moosajee, Vazira, Bell, Jimmy D., Speakman, John R., Batterham, Rachel L., Barsh, Gregory S., Ashford, Michael L.J., Withers, Dominic J.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Clinical Investigation 2005
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1069106/
https://ncbi.nlm.nih.gov/pubmed/15841180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200524445
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