Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease

We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimenta...

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Detalhes bibliográficos
Main Authors: Corrales, Milagros, Cardozo, Rubén, Segura, María Asunción, Urbina, Julio A., Basombrío, Miguel Angel
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1068647/
https://ncbi.nlm.nih.gov/pubmed/15793138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.4.1556-1560.2005
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