Defective CD4(+)CD25(+ )regulatory T cell functioning in collagen-induced arthritis: an important factor in pathogenesis, counter-regulated by endogenous IFN-γ

Mice with a deficiency in IFN-γ or IFN-γ receptor (IFN-γR) are more susceptible to collagen-induced arthritis (CIA), an experimental autoimmune disease that relies on the use of complete Freund's adjuvant (CFA). Here we report that the heightened susceptibility of IFN-γR knock-out (KO) mice is...

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Main Authors: Kelchtermans, Hilde, De Klerck, Bert, Mitera, Tania, Van Balen, Maarten, Bullens, Dominique, Billiau, Alfons, Leclercq, Georges, Matthys, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2005
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065335/
https://ncbi.nlm.nih.gov/pubmed/15743488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1500
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