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Generation of 5-(2′-deoxycytidyl)methyl radical and the formation of intrastrand cross-link lesions in oligodeoxyribonucleotides

Hydroxyl radical is one of the major reactive oxygen species (ROS) formed from γ-radiolysis of water or Fenton reaction, and it can abstract one hydrogen atom from the methyl carbon atom of thymine and 5-methylcytosine to give the 5-methyl radical of the pyrimidine bases. The latter radical can also...

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Bibliografski detalji
Glavni autori: Zhang, Qibin, Wang, Yinsheng
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2005
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1065259/
https://ncbi.nlm.nih.gov/pubmed/15767284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gki301
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