Both CD1d Antigen Presentation and Interleukin-12 Are Required To Activate Natural Killer T Cells during Trypanosoma cruzi Infection

Mechanisms of natural killer T (NKT)-cell activation remain unclear. Here, we report that during Trypanosoma cruzi infection, interleukin-12 (IL-12) deficiency or anti-CD1d antibody treatment prevents normal activation. The required IL-12 arises independently of MyD88. The data support a model of no...

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Detalhes bibliográficos
Main Authors: Duthie, Malcolm S., Kahn, Maria, White, Maria, Kapur, Raj P., Kahn, Stuart J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Fungal and Parasitic Infections
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064964/
https://ncbi.nlm.nih.gov/pubmed/15731095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.73.3.1890-1894.2005
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