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Identification of a SmD3 epitope with a single symmetrical dimethylation of an arginine residue as a specific target of a subpopulation of anti-Sm antibodies

Anti-Sm antibodies, identified in 1966 by Tan and Kunkel, are highly specific serological markers for systemic lupus erythrematosus (SLE). Anti-Sm reactivity is found in 5–30% of SLE patients, depending on the autoantibody detection system and the racial background of the SLE population. The Sm auto...

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Main Authors: Mahler, Michael, Fritzler, Marvin J, Blüthner, Martin
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064884/
https://ncbi.nlm.nih.gov/pubmed/15642139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1455
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