The critical role of arginine residues in the binding of human monoclonal antibodies to cardiolipin

Previously we reported that the variable heavy chain region (V(H)) of a human beta(2 )glycoprotein I-dependent monoclonal antiphospholipid antibody (IS4) was dominant in conferring the ability to bind cardiolipin (CL). In contrast, the identity of the paired variable light chain region (V(L)) determ...

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Detalhes bibliográficos
Main Authors: Giles, Ian, Lambrianides, Nancy, Latchman, David, Chen, Pojen, Chukwuocha, Reginald, Isenberg, David, Rahman, Anisur
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064879/
https://ncbi.nlm.nih.gov/pubmed/15642142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1449
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