The Na(+)–H(+ )exchanger-1 induces cytoskeletal changes involving reciprocal RhoA and Rac1 signaling, resulting in motility and invasion in MDA-MB-435 cells

INTRODUCTION: An increasing body of evidence shows that the tumour microenvironment is essential in driving neoplastic progression. The low serum component of this microenvironment stimulates motility/invasion in human breast cancer cells via activation of the Na(+)–H(+ )exchanger (NHE) isoform 1, b...

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Hauptverfasser: Paradiso, Angelo, Cardone, Rosa Angela, Bellizzi, Antonia, Bagorda, Anna, Guerra, Lorenzo, Tommasino, Massimo, Casavola, Valeria, Reshkin, Stephan J
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2004
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1064074/
https://ncbi.nlm.nih.gov/pubmed/15535843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/bcr922
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