Structure-Activity Study of the Lantibiotic Mutacin II from Streptococcus mutans T8 by a Gene Replacement Strategy

Mutacin II, elaborated by group II Streptococcus mutans, is a ribosomally synthesized and posttranslationally modified polypeptide antibiotic containing unusual thioether and didehydro amino acids. To ascertain the role of specific amino acid residues in mutacin II antimicrobial activity, we develop...

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Detalhes bibliográficos

Publicado no:	Appl Environ Microbiol
Principais autores:	Chen, Ping, Novak, Jan, Kirk, Marion, Barnes, Stephen, Qi, FengXia, Caufield, Page W.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1998
Assuntos:	Enzymology and Protein Engineering
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106391/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9647795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.64.7.2335-2340.1998
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