Structure-Activity Study of the Lantibiotic Mutacin II from Streptococcus mutans T8 by a Gene Replacement Strategy

Mutacin II, elaborated by group II Streptococcus mutans, is a ribosomally synthesized and posttranslationally modified polypeptide antibiotic containing unusual thioether and didehydro amino acids. To ascertain the role of specific amino acid residues in mutacin II antimicrobial activity, we develop...

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Bibliographic Details

Published in:	Appl Environ Microbiol
Main Authors:	Chen, Ping, Novak, Jan, Kirk, Marion, Barnes, Stephen, Qi, FengXia, Caufield, Page W.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 1998
Subjects:	Enzymology and Protein Engineering
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106391/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9647795/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.64.7.2335-2340.1998
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