ZPR1 Is Essential for Survival and Is Required for Localization of the Survival Motor Neurons (SMN) Protein to Cajal Bodies

Mutation of the survival motor neurons 1 (SMN1) gene causes motor neuron apoptosis and represents the major cause of spinal muscular atrophy in humans. Biochemical studies have established that the SMN protein plays an important role in spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis...

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Detalhes bibliográficos
Main Authors: Gangwani, Laxman, Flavell, Richard A., Davis, Roger J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061650/
https://ncbi.nlm.nih.gov/pubmed/15767679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.7.2744-2756.2005
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