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Genetic and Functional Interaction of Evolutionarily Conserved Regions of the Prp18 Protein and the U5 snRNA

Both the Prp18 protein and the U5 snRNA function in the second step of pre-mRNA splicing. We identified suppressors of mutant prp18 alleles in the gene for the U5 snRNA (SNR7). The suppressors' U5 snRNAs have either a U4-to-A or an A8-to-C mutation in the evolutionarily invariant loop 1 of U5....

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Autores principales: Bačíková, Dagmar, Horowitz, David S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2005
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061626/
https://ncbi.nlm.nih.gov/pubmed/15743809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.6.2107-2116.2005
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