The Exon 8-Containing Prosaposin Gene Splice Variant Is Dispensable for Mouse Development, Lysosomal Function, and Secretion

Prosaposin is a multifunctional protein with diverse functions. Intracellularly, prosaposin is a precursor of four sphingolipid activator proteins, saposins A to D, which are required for hydrolysis of sphingolipids by several lysosomal exohydrolases. Secreted prosaposin has been implicated as a neu...

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Detalles Bibliográficos
Main Authors: Cohen, Tsadok, Auerbach, Wojtek, Ravid, Liat, Bodennec, Jacques, Fein, Amos, Futerman, Anthony H., Joyner, Alexandra L., Horowitz, Mia
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2005
Assuntos:
Gene Expression
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1061615/
https://ncbi.nlm.nih.gov/pubmed/15743835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.6.2431-2440.2005
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