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Removal of C-Terminal Src Kinase from the Immune Synapse by a New Binding Protein
The Csk tyrosine kinase negatively regulates the Src family kinases Lck and Fyn in T cells. Engagement of the T-cell antigen receptor results in a removal of Csk from the lipid raft-associated transmembrane protein PAG/Cbp. Instead, Csk becomes associated with an ∼72-kDa tyrosine-phosphorylated prot...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Microbiology
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1061611/ https://ncbi.nlm.nih.gov/pubmed/15743820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.6.2227-2241.2005 |
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