Evaluation of Antimicrobial and Lipopolysaccharide-Neutralizing Effects of a Synthetic CAP18 Fragment against Pseudomonas aeruginosa in a Mouse Model

CAP18 (cationic antimicrobial protein; 18 kDa) is a neutrophil-derived protein that can bind to and inhibit various activities of lipopolysaccharide (LPS). The 37 C-terminal amino acids of CAP18 make up the LPS-binding domain. A truncated 32-amino-acid C-terminal fragment of CAP18 had potent activit...

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Veröffentlicht in:	Antimicrob Agents Chemother
Hauptverfasser:	Sawa, Teiji, Kurahashi, Kiyoyasu, Ohara, Maria, Gropper, Michael A., Doshi, Vatsal, Larrick, James W., Wiener-Kronish, Jeanine P.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1998
Schlagworte:	Biologic Response Modifiers
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC106033/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9835525/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.12.3269
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