Evaluation of Antimicrobial and Lipopolysaccharide-Neutralizing Effects of a Synthetic CAP18 Fragment against Pseudomonas aeruginosa in a Mouse Model

CAP18 (cationic antimicrobial protein; 18 kDa) is a neutrophil-derived protein that can bind to and inhibit various activities of lipopolysaccharide (LPS). The 37 C-terminal amino acids of CAP18 make up the LPS-binding domain. A truncated 32-amino-acid C-terminal fragment of CAP18 had potent activit...

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Autores principales: Sawa, Teiji, Kurahashi, Kiyoyasu, Ohara, Maria, Gropper, Michael A., Doshi, Vatsal, Larrick, James W., Wiener-Kronish, Jeanine P.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 1998
Materias:
Biologic Response Modifiers
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC106033/
https://ncbi.nlm.nih.gov/pubmed/9835525
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