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In Vitro and In Vivo Efficacy of the Triazole TAK-187 against Cryptococcus neoformans

Multiple isolates of Cryptococcus neoformans, including those with fluconazole resistance, were tested to assess the in vitro activity of the new triazole TAK-187. MICs of TAK-187 were at least eightfold lower than those of fluconazole, and fungicidal concentrations for most isolates were 4 μg/ml or...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Schell, Wiley A., De Almeida, Gisele Madeira Duboc, Dodge, Richard K., Okonogi, Kenji, Perfect, John R.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 1998
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC105909/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9756767/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.42.10.2630
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