Effects of α-Thalassemia on Pharmacokinetics of the Antimalarial Agent Artesunate

Thalassemia is common in Southeast Asia, where artemisinin derivatives are frequently used in the treatment of malaria. It has been previously reported that artemisinin derivatives can be concentrated by uninfected thalassemic erythrocytes in vitro but not by normal erythrocytes. As a follow-up to t...

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Main Authors: Ittarat, Wanida, Looareesuwan, Sornchai, Pootrakul, Pensri, Sumpunsirikul, Petchmanee, Vattanavibool, Phantip, Meshnick, Steven R.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 1998
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC105828/
https://ncbi.nlm.nih.gov/pubmed/9736558
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